Main Street Inn
404 S. Main St., Galena, IL 61036
Vacation Rentals
Located on Galena's historic downtown Main Street, the Main Street Inn is a cozy, inviting place to relax that is listed on the National Register of Historic Places (circa 1850).
Main Street Inn offers 6 luxurious and spacious rooms located on the 2nd floor that will meet the needs of romantic adventures, friend getaways, or anything in between. Walk out the front door to take a stroll up Main Street and browse through Galena's unique stores and boutiques, enjoy dining at one of Galena's fine restaurants, or stop by one of our wine shops. Or stay in and simply enjoy the comforts of your room.
Whatever your reason for coming to Galena, the Main Street Inn is here for you!
What's happening nearby...

Galena Country Fair
Grant Park • Oct 11 – Oct 12 @ 10AM
One of Galena's most popular events featuring more than 100 vendors selling a variety of high-quality, original handmade arts, crafts and fine arts!
Read more about Galena Country Fair
Twenty Dirty Hands Self-Guided Pottery Tour
Multiple Locations • Oct 17 – Oct 19 @ 10AM
Join in the 24th edition of the Tri-State region’s only self-guided pottery tour, October 17 - 29, 2025.
Read more about Twenty Dirty Hands Self-Guided Pottery Tour
Other Side of the Anvil
Lawn adjacent to the Stillman Mansion • Oct 18 – Oct 19 @ 10AM
Two-day blacksmithing event that features forging and historic demonstrations, like broom tying. This is a unique opportunity to work hands-on with a coal forge and gain…
Read more about Other Side of the AnvilYou might also be interested...

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